Brock Purdy and the undefeated 49ers are big favorites in their Monday night matchup with the Commanders. Darren Yamashita/Imagn ImagesESPNMultiple AuthorsOct 16, 2026, 01:30 PM ETOpen Extended ReactionsThe Denver Broncos upset the Seattle Seahawks on Thursday to get Week 6 underway. The defending champion Seahawks entered as 2.5-point favorites but fell 17-14 in overtime.Kicking off Sunday’s play is an AFC South matchup between the Houston Texans and Jacksonville Jaguars in London (9:30 a.m. ET start).The Los Angeles Rams are the biggest favorite of the week, laying 12.5 points at home versus the Arizona Cardinals. The total for the game is 51.5, one of five games with a total over 50.The Dallas Cowboys, coming off a loss to the previously winless Tampa Bay Buccaneers, head to Lambeau Field to take on the Green Bay Packers on Sunday night, and the San Francisco 49ers host the Washington Commanders on “Monday Night Football” (8:15 p.m.
ET on ESPN/ABC) to close out the week.The Cincinnati Bengals, Detroit Lions, Miami Dolphins and Minnesota Vikings are on bye. Here’s a look at the odds for every game this week. (You can find early bets we like here.)Note: Odds by DraftKings and subject to change. All times Eastern.Jump to: SEA-DEN | HOU-JAX | CHI-ATL | TEN-IND CAR-PHI | NYJ-NE | BAL-CLE | NO-NYG PIT-TB | ARI-LAR | BUF-LV | LAC-KC DAL-GB | WSH-SFHouston Texans vs. Jacksonville Jaguars -2.5 Sunday, 9:30 a.m., NFL NetMoneyline: Texans (+124); JAGUARS (-148) Total: 42.5; Opened: 41.5 FPI favorite: Jaguars by 2.3 with a 59% probability to win the game outrightChicago Bears -1.5 vs.
Atlanta Falcons Sunday, 1 p.m., FoxMoneyline: Bears (-118); Falcons (-102) Total: 51.5; Opened: 47.5 FPI favorite: Bears by 2.9 with a 61% probability to win the game outrightCheck out the latest Super Bowl odds and major NFL awards futures.Tennessee Titans vs. Indianapolis Colts -7 Sunday, 1 p.m., FoxMoneyline: Titans (+280); Colts (-355) Total: 44.5; Opened: 48.5 FPI favorite: Colts by 6.1 with a 72% probability to win the game outrightCarolina Panthers -3.5 vs. Philadelphia Eagles Sunday, 1 p.m., CBSMoneyline: Panthers (-185); Eagles (+154) Total: 38.5; Opened: 43.5 FPI favorite: Panthers by 2 with a 58% probability to win the game outrightNew York Jets vs. New England Patriots -7.5 Sunday, 1 p.m., CBSMoneyline: Jets (+275); Patriots (-345) Total: 43.5; Opened: 42.5 FPI favorite: Patriots by 8.3 with a 80% probability to win the game outrightBaltimore Ravens -3.5 vs.
Cleveland Browns Sunday, 1 p.m., FoxMoneyline: Ravens (-205); Browns (+170) Total: 40.5; Opened: 44.5 FPI favorite: Ravens by 4.4 with a 66% probability to win the game outrightNew Orleans Saints -1.5 vs. New York Giants Sunday, 1 p.m., FoxMoneyline: Saints (-112); Giants (-108) Total: 45.5; Opened: 45.5 FPI favorite: Saints by 1.3 with a 55% probability to win the game outrightPittsburgh Steelers -2.5 vs. Tampa Bay Buccaneers Sunday, 1 p.m., CBSMoneyline: Steelers (-148); Buccaneers (+124) Total: 39.5; Opened: 45.5 FPI favorite: Steelers by 2.3 with a 59% probability to win the game outrightArizona Cardinals vs. Los Angeles Rams -12.5 Sunday, 4:05 p.m., FoxMoneyline: Cardinals (+575); Rams (-850) Total: 51.5; Opened: 46.5 FPI favorite: Rams by 11.9 with a 87% probability to win the game outrightBuffalo Bills -4.5 vs.
Las Vegas Raiders Sunday, 4:25 p.m., CBSMoneyline: Bills (-205); Raiders (+170) Total: 53.5; Opened: 47.5 FPI favorite: Bills by 6.1 with a 72% probability to win the game outrightLos Angeles Chargers vs. Kansas City Chiefs -7.5 Sunday, 4:25 p.m., CBSMoneyline: Chargers (+360); Chiefs (-470) Total: 41.5; Opened: 46.5 FPI favorite: Chiefs by 6.7 with a 75% probability to win the game outrightDallas Cowboys vs. Green Bay Packers -1.5 Sunday, 8:20 p.m., NBCMoneyline: Cowboys (+100); Packers (-120) Total: 53.5; Opened: 51.5 FPI favorite: Cowboys by 0.6 with a 52% probability to win the game outrightWashington Commanders vs. San Francisco 49ers -7.5 Monday, 8:15 p.m., ESPN, ABCMoneyline: Commanders (+330); 49ers (-425) Total: 51.5; Opened: 50.5 FPI favorite: 49ers by 11.3 with a 86% probability to win the game outrightThursday’s resultBroncos 17, Seahawks 14 (OT)Seattle Seahawks -2.5 vs.
Denver Broncos Thursday, 8:15 p.m., Prime VideoMoneyline: Seahawks (-142); Broncos (+120) Total: 40.5; Opened: 43.5 FPI favorite: Seahawks by 0.7 with a 53% probability to win the game outright
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